Clinical and public health approaches to diagnosis and management of zoonotic infections

Zoonotic infections, which are diseases naturally transmitted between animals and humans, represent a persistent and escalating threat to global health security. These infections account for a significant proportion of both endemic and emerging infectious diseases, including high-impact pathogens such as SARS-CoV-2, H1N1 influenza, Nipah virus, and avian influenza. The epidemiology of zoonoses is influenced by complex interactions among environmental changes, human behavior, animal health, and socio-economic factors. This necessitates an integrated approach to diagnosis, prevention, and management.Clinically, the diagnosis of zoonotic diseases remains challenging due to their often nonspecific symptoms, overlapping with other common infections. Timely and accurate diagnosis relies on a combination of traditional techniques such as microscopy, culture, and serology, alongside modern molecular diagnostics including PCR, ELISA, and next-generation sequencing. These methods not only enhance pathogen detection but also facilitate early outbreak identification and containment.From a public health perspective, a One Health approach—integrating human, animal, and environmental health—is essential for effective management. Strategies include establishing robust surveillance systems, vector control programs, community education, risk communication, and vaccination efforts in both humans and animal reservoirs. Cross-sector collaboration between medical, veterinary, and ecological disciplines is key to implementing sustainable interventions.Moreover, the paper reviews case studies that illustrate successful zoonotic outbreak responses and highlights gaps in global preparedness, particularly in resource-limited settings. Challenges such as insufficient diagnostic infrastructure, lack of coordinated policies, and underreporting are discussed, along with future priorities including policy integration, capacity building, and investment in early-warning systems.This review underscores the critical importance of aligning clinical management with public health strategies to effectively control zoonotic infections. Adoption of a unified, interdisciplinary approach will be instrumental in reducing disease burden, mitigating pandemic risks, and ensuring global health resilience.