GLUT DNA TRANSFER METHOD INTO THE HUMAN OR ANIMAL CELLS

Based on the compelling in vitro evidence, glucose-conjugated DNA vectors emerge as a highlypromising platform for targeted gene therapy. This strategy successfully hijacks the cell'sabundant and ubiquitous glucose transport machinery, overcoming the primary barrier of cellularentry that has long plagued non-viral gene delivery. The demonstrated efficiency and specificityof this glucose-facilitated uptake position it as a major application, particularly for treatingmetabolic diseases and cancers where target cells exhibit a voracious demand for glucose. Byexploiting this natural metabolic pathway, this technology paves the way for smarter, moreefficient, and tissue-specific genetic medicines with reduced off-target effects, representing asignificant leap forward in the safe and effective clinical application of gene therapy.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-10-25
DOI
https://doi.org/10.5281/zenodo.17439906
Primary Topic
Historical Studies on Reproduction, Gender, Health, and Societal Changes
Type
article
Field-Weighted Citation Impact
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article

GLUT DNA TRANSFER METHOD INTO THE HUMAN OR ANIMAL CELLS

Zenodo (CERN European Organization for Nuclear Research)
Historical Studies on Reproduction, Gender, Health, and Societal Changes
article

GLUT DNA TRANSFER METHOD INTO THE HUMAN OR ANIMAL CELLS

article en

Abstract

Based on the compelling in vitro evidence, glucose-conjugated DNA vectors emerge as a highlypromising platform for targeted gene therapy. This strategy successfully hijacks the cell'sabundant and ubiquitous glucose transport machinery, overcoming the primary barrier of cellularentry that has long plagued non-viral gene delivery. The demonstrated efficiency and specificityof this glucose-facilitated uptake position it as a major application, particularly for treatingmetabolic diseases and cancers where target cells exhibit a voracious demand for glucose. Byexploiting this natural metabolic pathway, this technology paves the way for smarter, moreefficient, and tissue-specific genetic medicines with reduced off-target effects, representing asignificant leap forward in the safe and effective clinical application of gene therapy.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 39%
Historical Studies on Reproduction, Gender, Health, and Societal Changes
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