DETERMINATION OF PHARMACEUTICAL COMPOUNDS VIA N-BROMOSUCCINIMIDE AND RHODAMINE-B COUPLED SPECTROPHOTOMETRY

Simple, sensitive and selective methods are developed for the spectrophotometric determination of drugs, viz., Montelukast sodium, Prasugrel, Ondensetron, Rosuvastatin calcium, Amlodepine besylate based on their reactivity towards N- bromosuccinimide (NBS). The method involves the addition of excess NBS of known concentration in the presence of 1M HCl, reactants are allowed to react and the unreacted NBS is estimated by the measurement in the decrease in the absorbance of the Rhodamine-B dye (λmax 557nm). This method has been applied for the determination of drugs in their pure form as well as in tablet formulations