ANALYTICAL METHOD USING NBSA REAGENT FOR QUANTIFICATION OF PURE AND PHARMACEUTICAL ANTIHISTAMINE DRUGS

A quick and convenient method has been developed for the micro estimation of antihistamine drugs. 1-5 mg of sample is allowed to react with 10 ml of 0.02 M, N-bromosaccharin solution. Unconsumed reagent can be accurately titrated with 5 ml of 15% KI and 0.02N sodium thiosulphate solution using starch as indicator. SD and CV was calculated for reproducible and accurate result. The accuracy of the method is within + 1 % and possible course of reaction was suggested on the basis of stoichiometry as well as find reaction product.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-10-24
DOI
https://doi.org/10.5281/zenodo.17433174
Primary Topic
Business Strategies and Innovation
Type
article
Field-Weighted Citation Impact
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article

ANALYTICAL METHOD USING NBSA REAGENT FOR QUANTIFICATION OF PURE AND PHARMACEUTICAL ANTIHISTAMINE DRUGS

Zenodo (CERN European Organization for Nuclear Research)
Business Strategies and Innovation
article

ANALYTICAL METHOD USING NBSA REAGENT FOR QUANTIFICATION OF PURE AND PHARMACEUTICAL ANTIHISTAMINE DRUGS

article en

Abstract

A quick and convenient method has been developed for the micro estimation of antihistamine drugs. 1-5 mg of sample is allowed to react with 10 ml of 0.02 M, N-bromosaccharin solution. Unconsumed reagent can be accurately titrated with 5 ml of 15% KI and 0.02N sodium thiosulphate solution using starch as indicator. SD and CV was calculated for reproducible and accurate result. The accuracy of the method is within + 1 % and possible course of reaction was suggested on the basis of stoichiometry as well as find reaction product.

Zenodo (CERN European Organization for Nuclear Research)
Central University of South Bihar (IN)
Openalex Percentile: Top 34%
Business Strategies and Innovation
DOIOpen Access PDFOpenAlex
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ANALYTICAL METHOD USING NBSA REAGENT FOR QUANTIFICATION OF PURE AND PHARMACEUTICAL ANTIHISTAMINE DRUGS · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS