Evaluation of antiarthritic activity of ethanolic extract of Boswellia serrata on CFA induced method in albino rats

Rheumatoid arthritis (RA) is an autoimmune, inflammatory condition mainly characterized by inflammation of the synovial membranes. It predominantly affects women ages 30 to 50, with a prevalence rate of 1in 150.The present study was to evaluate the anti-arthritic activity of ethanolic extract of Boswellia Serrata Bark in complete Freund’s adjuvant (CFA)-induced arthritic rats.Arthritis was induced by sub-cutaneous injection of 0.1 ml of CFA in rats. Arthritic arts were divided into different groups and ethanolic extract of Boswellia Serrata Bark (EEBSB) was administered at doses of 100 and 200 mg/kg, p.o for 15 days. The control group received Normal saline. Diclofenac (10 mg/kg, i.p) was used as a standard drug. Paw volumes were recorded on 0, 5and 15 day using a plethysmometer. Blood samples were collected at the end of the experiment from all the groups to analyze the serological rheumatic factors: C-reactive protein (CRP), serum rheumatic factor (SRF) and hematological parameters. EEBSB was also tested for protein denaturation and membrane stabilization activities The collected data were analyzed using paired t-tests and analysis of variance (ANOVA) with SPSS. The data were analyzed and presented as mean differences. A P-value of < 0.05 was considered statistically significant." The EEBSB (100 and 200 mg/kg, p.o) showed significant (P < 0.01, P < 0.05) reduction in paw volume, change in body weight in CFA rats at 15 day when compared with arthritic control rats. The results obtained from the present study revealed the potential anti-arthritic activity of ethanolic extract from the Barkof B. Serrat.