Quantifying the Long and Short Axes of the External Iliac Lymph Nodes Using Dual-Energy Computed Tomography: A Potential Diagnostic Approach for Periprosthetic Joint Infection – A Prospective Study

Yaji Yang,1– 3,* Haotian Zhou,1– 3,* Runxing Kang,1– 3 Chen Zhao,1– 3 Jia Li,4 Feilong Li,1– 3 Yidong Shen,1– 3 Yuelong Chen,5 Wei Huang,1– 3 Leilei Qin1– 3 1Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Chongqing, People’s Republic of China; 3Orthopaedic Research Laboratory of Chongqing Medical University, Chongqing, People’s Republic of China; 4Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 5Hospital of Chongqing University, Chongqing University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Huang; Leilei Qin, Department of Orthopaedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China, Email [email protected]; [email protected]: Periprosthetic joint infection (PJI) is a severe complication following joint replacement surgery, and there is a current lack of rapid, accurate, and non-invasive diagnostic methods. This study aims to assess the effectiveness of using dual-energy computed tomography (DECT) to quantify the maximum long and short axes of the external iliac lymph nodes (LNs) as a diagnostic tool for PJI.Patients and Methods: In this prospective controlled study, 112 patients undergoing total hip or total knee revision surgery were enrolled. All patients underwent preoperative DECT scanning to measure the maximum long and short axes of the external iliac LNs on the affected side. The diagnostic value of lymph node size for PJI was assessed using receiver operating characteristic curves.Results: The AUC (Area Under the Curve) quantifies the diagnostic method’s ability to distinguish between positive and negative outcomes in this study. A value closer to 1.0 indicates better discriminatory performance. Compared to erythrocyte sedimentation rate (Area Under the Curve (AUC) = 0.834), percentage of polymorphonuclear leukocytes (AUC = 0.621), and C-reactive protein (AUC = 0.765), the maximum long axis (AUC =0.895) and maximum short axis (AUC = 0.858) of the external iliac LNs better differentiated PJI from aseptic failure. For diagnosing PJI, the threshold for the maximum long axis of the LNs was 20.5 mm, with a sensitivity of 84.21% and a specificity of 87.84%. For the maximum short axis, the threshold was 8.5 mm, with a sensitivity of 89.47% and a specificity of 82.43%. Combining the maximum long and short axes of the external iliac LNs enhanced the diagnostic accuracy for PJI.Conclusion: Measuring the long and short axes of external iliac LNs using DECT is an effective diagnostic approach for PJI, aiding in the differentiation between PJI and aseptic failure following joint replacement surgery.Keywords: periprosthetic joint infection, diagnosis, dual-energy CT, lymph nodes