MON-164 Pregnancy Outcomes in Women with History of Bariatric Surgery During Adolescence

Abstract Disclosure: T. Keys: None. S. Jang: None. T. Jenkins: None. M. Michalsky: None. T. Inge: None. J. Josefson: None. J.R. Ryder: None. Objectives: Women with severe obesity face higher risks for pregnancy-related comorbidities such as gestational diabetes (GDM) and pre-eclampsia. However, the rates of development of these comorbidities following metabolic and bariatric surgery (MBS) are unknown. This study characterized pregnancy-related comorbidities and outcomes in women who underwent MBS as adolescents and compared these findings with national norms. Study Design We analyzed pregnancy outcomes from 88 mothers who participated in the Teen-LABS (Longitudinal Assessment of Bariatric Surgery) study. Participants in the Teen-LABS cohort were measured at baseline, 6 months, and annually thereafter. Following pregnancy, women completed an additional Reproductive Health Pregnancy Questionnaire which provided detailed information about their pregnancy. The cohort has experienced minimal loss (88% retention) to follow-up, ensuring robust data collection. Data represent descriptive outcomes over a multiyear time course. Descriptive statistics are summarized. Results: A total of 135 pregnancies (mean pre-pregnancy BMI = 37.8 kg/m2) were observed: 105 live births, 21 miscarriages, 7 abortions, 1 ectopic pregnancy, and 1 stillbirth occurred between 4 months and 14 years post-MBS. The average weight gain during pregnancy was 30.9 pounds, exceeding the Institute of Medicine-recommended range of 11-20 pounds for women with obesity. Among the live births, 9.5% developed pre-eclampsia, resulting in 8 hospitalizations. Thirteen pregnancies were complicated by GDM (12.4%), which is higher than US normative data for women aged 20-29 (4.5-6.6%), with 3 requiring medication, 1 requiring insulin, and 1 requiring hospitalization. Seven live births had premature rupture of the membranes before 37 weeks, with one birth as early as 26 weeks. The cesarean section rate was 48.4%, which is higher than US normative data for women aged 20-29 (28%). Breastfeeding was initiated in 66% though was discontinued by the majority of participants (78.9%) within the first three months. Conclusion: Elevated cesarean section rates , GDM diagnoses and pre-eclampsia rates warrant further investigation in women with previous MBS. Whether these comorbidities are due to obesity in pregnancy or related to previous MBS is unknown. Further research should evaluate post-pregnancy weight changes, long-term maternal health, and the health outcomes for the offspring of this cohort. Presentation: Monday, July 14, 2025