SUN-585 Global Mortality Trends of Chronic Kidney Disease in Older Adults with Type 1 Diabetes: A 204-Country Analysis from 1990 to 2021

Abstract Disclosure: H. Ilyas: None. A. Akram: None. A. Shafi: None. H. Ilyas: None. M. Haider: None. M. Khan: None. I. Ahmad: None. H. Ahmad: None. M. Kakakhel: None. Introduction: Chronic kidney disease (CKD) is a commonly occurring and debilitating complication of type 1 Diabetes Mellitus, which has the potential to significantly affect multiple facets and frequently results in fatal complications. This study evaluates global mortality trends attributable to CKD among individuals with Type 1 Diabetes aged 55 years and older from 1990 to 2021. By analyzing data from 204 countries, we aim to identify regions with rising death rates and to inform targeted public health interventions. Methods: We analyzed data from the Global Burden of Disease (GBD) Study, focusing on individuals aged 55 and above with Type 1 Diabetes who died from CKD. Mortality trends per 100,000 population were examined using the estimated annual percentage change (EAPC) alongside 95% confidence intervals across 204 countries. Results: China demonstrated the highest number of CKD-related deaths in both 1990 and 2021, indicating a substantial and escalating health burden. In 1990, China recorded 5,308 deaths (95% CI: 3,474-7,733), which increased to 9,288 deaths by 2021(95% CI: 6,075-13,607). Ukraine had the highest increase in death rates from 1990 to 2021, with EAPC of 22.09 (95% CI: 16.00-29.03), reflecting a significant surge in CKD mortality. Similar increasing trends were observed in Belarus and Armenia, where death rates were rising as well. In contrast, Kuwait saw the largest improvement, effectively reducing CKD-related deaths with a rate of -0.62 (95% CI: -0.70 to -0.52). Other nations, including the Republic of Korea, Poland, Singapore, and Spain also demonstrated notable declines in mortality rates. Conclusion: This study highlights significant disparities in the management of CKD among older adults with Type 1 Diabetes worldwide. While some countries have successfully mitigated CKD-related mortality, others, such as Ukraine, continue to face rising death rates. These findings underscore the need for focused, region-specific strategies to address CKD and to refine healthcare policies in high-burden areas. Presentation: Sunday, July 13, 2025