ASSOCIATION OF CORE METABOLIC SYNDROME MARKERS WITH NONALCOHOLIC FATTY LIVER DISEASE

Objectives: The present study was undertaken to explore whether MetS and its individual components are associated with NAFLD. Materials and methods: 67 diagnosed NAFLD subjects and 50 healthy controls were included. NAFLD was diagnosed by ultrasound and serum C-peptide was measured by Immulite technique. Results: The NAFLD and control subjects were age and BMI- matched (age in years, p=0.380 and BMI in kg/m2, p=0.763). On logistic regression analysis, taking NAFLD as the dependent variable a significant association was found with low HDL (p<0.001), WHR, PSG and dyslipidemia (p=0.019, p=0.031, p=0.001 respectively). Conclusions: Nonalcohlic fatty liver disease (NAFLD) does not seem to be associated with MetS in Bangladeshi population as defined by the 3 major criteria provided by IDF, ATP III and WHO. Various components of MetS like central obesity, dyslipidemia, hypertension, and diabetes are associated with NAFLD. However, they do not seem to cluster in the manner as predicted by IDF, ATP III and WHO criteria.