SUN-599 Factors Associated with Erectile Dysfunction in Patients with Type 2 Diabetes Mellitus at a Tertiary Hospital in the Philippines: An Analytical Cross-sectional Study

Abstract Disclosure: F.P. Salvador-Badilles: None. S.O. Paragas: None. P. Lim: None. M. Relucio: None. S. Kevin Rigor: None. P.D. Maningat: None. Background: One of the overlooked complications that affects the quality of life of men with Type 2 Diabetes Mellitus (DM) is Erectile Dysfunction (ED). ED is considered an early sign of DM neuropathy and increases with age and duration of DM. A 2022 study showed that patients with DM have a 3.5 fold higher prevalence of ED compared to those without DM. A study showed that the Philippines has the highest prevalence of ED in Asian males. There is no data on the prevalence of ED with Type 2 DM in the Philippines. The study aims to provide local data on the prevalence of ED on Type 2 DM patients and identify associated factors such as age, BMI, glycemic control, duration of DM, smoking and alcohol use, comorbidities (e.g. hypertension, heart disease, kidney disease, dyslipidemia, stroke), DM Complications (e.g. Cardiovascular, Neuropathy, Nephropathy, Retinopathy, DM Foot), and total testosterone. Methodology: An analytical cross-sectional study involving 164 male patients with Type 2 DM was conducted at a Wellness Center of a tertiary hospital in the Philippines. Participants were asked by the authors about smoking and alcohol use, comorbidities, and DM Complications. The participants completed the International Index of Erectile Function Questionnaire (IIEF-5), a validated tool for identifying and classifying ED. An IIEF-5 score of 5–21 indicates the presence of ED. HbA1c and BMI were obtained from the EMR. Total testosterone levels were obtained in all patients and levels were determined using the enzyme chemiluminescence method with the Siemens Atellica IM 1300 Analyzer. Descriptive statistics was done for demographic profile and clinical characteristics. Determination of factors associated with ED were analyzed using univariate and multivariate statistics. Chi square test and logistic regression was used in the univariate analysis. Odds ratio and the 95% confidence interval was calculated. Multiple logistic regression was utilized in the multivariate analysis. Results: Among male patients with Type 2 DM, there was a prevalence of 66.5% of ED, most were mild ED. For every year increase in age, odds of ED increased by 10%, OR 1.11 (90% CI 1.063-1.15). Alcohol intake was protective of ED, OR 0.32 (90% CI 0.14-0.73). There was a statistically significant correlation between ED and DM complications, specifically DM Retinopathy OR 3.41(95% CI 1.12-10.42). There was no statistically significant correlation between duration of DM, severity of ED, BMI, smoking, glycemic control, comorbidities and total testosterone,. Conclusion: The high prevalence of ED among patients with Type 2 DM indicates the need for increased surveillance. Concurrent DM complications should prompt thorough evaluation in patients with ED, conversely, the presence of ED should prompt assessment for potential DM complications. Stigma of ED leads to underreporting hence comprehensive history is essential for early identification. Presentation: Sunday, July 13, 2025