Complications of Chronic Inhaled Glucocorticoid Therapy in Asthma Treatment

Abstract: Asthma is a chronic inflammatory disease of the airways, and its treatment includes the use of inhaled glucocorticoids (ICS). ICS are considered the first-line therapy for controlling asthma symptoms and preventing disease progression. However, long-term use of these medications is associated with the risk of various complications that may affect patients' health. This study discusses the potential complications related to prolonged ICS use, such as oral infections, osteoporosis, hormonal imbalances, and the risk of adrenal dysfunction. The analysis also covers risk factors for these complications, including drug dosage, duration of use, and individual patient characteristics. Additionally, the study proposes strategies to minimize the risk of complications, such as dose optimization, proper inhalation technique, patient health monitoring, and the development of new treatment methods. The aim of this paper is to provide insight into the balance between the benefits of ICS therapy and the potential risks associated with their long-term use.