MON-520 Comparison of Oral and Intramuscular Vitamin B12 Supplementation in Metformin-Treated Diabetes Mellitus Patients With Vitamin B12 Deficiency

Abstract Disclosure: A.C. Sonwane: None. S.G. Kandula: None. B.K. Sethi: None. A.N. Ambekar: None. K.D. Modi: None. S. Naidu: None. Introduction:Metformin usage is linked to vitamin B12 deficiency, but no standardised treatment protocols exist for its treatmentAim and Objective:To compare the effectiveness of oral (O) Vs Intramuscular (IM) B12 for the correction of B12 deficiency and to assess its prevalenceMaterials and Methods: We screened 107 consecutive diabetic patients attending a Tertiary care centre who were onat least 1000 mg of Metformin for one year or more for vitamin B12 deficiency. Sixty-five patients were male with an M:F ratio of 1.6:1, and 83 patients were non-vegetarian. The mean age, duration of diabetes and daily metformin dose in O and IM groups was 55.29 9.26 years Vs 48.94 10.91 yrs, 9.34 5.57 Vs 8.59 5.21 yrs and 1616.18 465.27 mg Vs 1760.56 395.14, respectively. The deficient patients were randomly assigned to receive B12 O or IM and assessed for B12, homocysteine, serum folate, and complete blood picture at baseline, 3 and 6 months; The oral group were given vitamin B12 (Methylcobalamin)1000 mcg/day for 6 months and the IM group 1000 mcg once a week for 6 weeks followed by once in 3 months. Statistical analysis was done with Pearson correlation, Chi-squared tests, and independent t-tests. Results: The baseline,3 months and 6 months, vitamin B12 levels for 68 deficient patients in the O and IM group were 125.34 40.48 pg/ml Vs 110.56 39.74 pg/ml, 401.39 233.01 pg/ml Vs 470.62 422.58 pg/ml, 332.95 151.25 pg/ml Vs 412.80 321.56 pg/ml and not significantly different. There were no significant differences in homocysteine, Haemoglobin and mean corpuscular volume levels were unaffected by the treatment.Discussion and Conclusion: Vitamin B12 deficiency is prevalent in metformin-treated T2DM, and oral vitamin B12 is aseffective as IM for its correction while offering convenience, simplicity and avoiding the need for an HCP visit for prescription and administration Keywords: Metformin-treated diabetes, vitamin B12 deficiency, Optimal Vitamin B12Supplementation. Presentation: Monday, July 14, 2025