SAT-272 Association between handgrip strength and triglyceride glucose index based on the Korean National Health and Nutrition Examination Survey

Abstract Disclosure: S. Lee: None. Handgrip strength (HGS) is a simple, reliable method to measure muscle strength and assessing sarcopenia. Insulin resistance (IR) is important contributing factor to cardiovascular disease and also related with sarcopenia. In this study, we investigated the association between IR and muscle strength via the Triglyceride glucose index (TyG) index and HGS. We used data from the sixth Korean National Health and Nutrition Examination Survey to evaluate a total of 10048 subjects aged over 40. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2] to represent IR. We defined absolute HGS as sum of the maximum values of the right and left sides of each of the three measurements. The relative HGS was calculated by dividing the absolute HGS by body mass index. Correlation analysis was performed between the TyG index and relative HGS. The subjects were stratified into quartiles according to the TyG index. Relative HGS was decreased as the TyG index increased in total subjects. In linear regression analysis, relative HGS showed negative correlation with metabolic parameter and the TyG index in all groups of age and gender. According to logistic regression analysis after adjusting for multiple risk factors, odds ratio (95% CI) for low muscle strength (defined as the lower 10% on relative HGS) for the highest and lowest quartiles of the TyG index was 2.513 in male and 2.161 in female on total subjects. In group of subjects with mid-age (age between 40 to 64 years old), the prevalence of low muscle strength was positively correlated with increased the TyG index both in male and female. However, in the elderly groups (age over 65 years old), relationships between the increased the TyG index quartiles and prevalence of low muscle strength were not significant in all subjects both in unadjusted and adjusted logistic regression analysis. In conclusion, the TyG index was independently associated with relative HGS and low muscle strength in mid-aged subject and could have predictive value for further sarcopenia and metabolic disease. Presentation: Saturday, July 12, 2025