Precision medicine in hypertension: from pharmacogenomics to tailored treatment algorithms

The aim of this research was to investigate the application of precision medicine in the treatment of hypertension, focusing on the role of genetics and personalized treatment algorithms in different Uzbekistan populations. Samples were collected from five large cities of the nation with different genetic and environmental characteristics. The results showed that the distribution of efficient genotypes for response to antihypertensive drugs, such as the CACNA1C and ACE genes, is heterogeneous in these populations and has a direct impact on the regulation of blood pressure and the occurrence of drug side effects. Genetically profiled treatment reduced mean blood pressure by 13-15 mmHg within 12 weeks and minimized complications in patients. Lifestyle also supplemented the function of increasing treatment response. The findings confirm the importance of the use of genetic, clinical, and behavioral information in creating efficacious treatment regimens. The study played an important role in improving the personalized and effective control of hypertension in Uzbekistan's heterogeneous populations and paved the way for precision medicine implementation in the country.