SUN-194 Pituitary Function After Moderate to Severe Head Trauma in Children

Abstract Disclosure: W. Morales: None. D. Ramirez: None. V. Leal: None. S. Awadalla: None. Introduction: Traumatic brain injury (TBI) is the main cause of death and disability in the pediatric population. Hypopituitarism is an important complication that can develop after TBI and is usually overlooked. The reported prevalence varies between 5-57% of cases, being more frequent in patients with moderate or severe TBI. The study's objective was to evaluate pituitary function after moderate to severe TBI in two pediatric reference centres in Bogotá D.C., Colombia between 2020-2024. Methods: 27 patients ( 19 males, 8 females) with TBI were included (moderate: N = 12; severe: N = 15). Severe TBI was more frequent in male patients (66.6%). Age was: 10.7 ± 4.97 ( M ± SD ) years. Basal concentrations of TSH, FT4, IGF-1, Cortisol AM, and Prolactin were evaluated after 6 months of the traumatic injury. Results: Post-traumatic hormonal alterations compatible with GH deficiency were observed given IGF-1 levels lower than the 3rd percentile in 2 of the 27 patients (7.40%) confirmed with a low peak in the GH stimulation test. There was no relationship with the severity of trauma No alterations were found in the rest of the pituitary axes in the other participants. Conclusion: A prevalence of hypopituitarism, especially growth hormone deficiency, was found in 7.40% of patients with a history of moderate or severe TBI. This complication should be screened in the multidisciplinary follow-up of these patients, as it increases morbidity and mortality rates and deteriorates the quality of life of patients after TBI. Presentation: Sunday, July 13, 2025