SUN-584 The Impact of Chronic Kidney Disease on Disability-Adjusted Life Years in Older Adults with Type 1 Diabetes: A Global Analysis from 1990 to 2021

Abstract Disclosure: H. Ilyas: None. M. Haider: None. A. Akram: None. H. Ilyas: None. A. Shafi: None. M. Kakakhel: None. M. Khan: None. I. Ahmad: None. S. Khan: None. H. Ahmad: None. Background & Objective: Chronic kidney disease (CKD) is a significant and increasing public health concern, particularly among individuals with type 1 diabetes mellitus (T1DM). This study provides a systematic analysis of the global burden of CKD, quantified using disability-adjusted life years (DALYs), to evaluate temporal trends from 1990 to 2021. By assessing the estimated annual percentage change (EAPC) in DALYs across 204 countries, this analysis identifies regions experiencing the greatest increases and decreases in disease burden, offering insights into global disparities and progress in CKD management. Methods: Data from the Global Burden of Disease (GBD) Study were analyzed to examine DALYs attributable to CKD in adults aged 55 years and older with comorbid T1DM. EAPC values, with 95% confidence intervals (CIs), were measured to assess temporal trends in disease burden across different nations. Countries exhibiting the most substantial increases and decreases in DALYs were identified, with rigorous statistical validation ensuring the accuracy of estimates. Results: China consistently reported the highest CKD-related DALYs in both 1990 and 2021, reflecting a significant and persistent disease burden. In 1990, China recorded 162,762 DALYs (95% CI: 106,333–239,052), which escalated to 289,931 DALYs (95% CI: 190,126–427,449) by 2021. Ukraine exhibited the highest increase in CKD-related DALYs, with an EAPC of 4.77 (95% CI: 2.90–7.97), followed by Armenia and Belarus, indicating a rising disease burden in these regions. Conversely, the Maldives demonstrated the greatest decline in EAPC (-6.04, 95% CI: -0.70 to -0.46), signifying notable progress in reducing CKD-related DALYs. Other countries with declining EAPC included Kuwait, Ethiopia, Poland, and South Korea. These findings highlight pronounced geographical variations, with some nations experiencing worsening CKD burdens while others demonstrate effective mitigation strategies. Conclusion: This analysis underscores the growing global disparity in CKD-related DALYs among individuals with T1DM. Countries such as Ukraine, Armenia, and Belarus exhibit rising disease burdens, necessitating urgent, targeted public health interventions. In contrast, nations such as the Maldives have demonstrated significant progress, offering potential models for effective CKD mitigation strategies. These findings emphasize the need for region-specific policies to address the increasing burden of CKD and reduce global health disparities. Presentation: Sunday, July 13, 2025