MON-417 Geographic, Racial, and Gender Disparities in Thyrotoxicosis-Related Mortality in the United States (1999-2020)

Abstract Disclosure: E. Assaf: None. A. Musallam: None. H. Munshi: None. A. Shubietah: None. A. Hammad: None. I. Rajab: None. A. Ahmad: None. B. Khatiashvili: None. J. Lopez: None. Background: Thyrotoxicosis, a potentially life-threatening endocrine disorder, can lead to severe cardiovascular and metabolic complications if untreated. Despite advancements in medical management, disparities in mortality persist. This study evaluates geographic, racial, and gender variations in thyrotoxicosis-related mortality in the United States over two decades. Methods: A retrospective analysis of thyrotoxicosis-related deaths from 1999 to 2020 was conducted using CDC WONDER data. Crude and age-adjusted mortality rates (AAMR) per 100,000 population were analyzed, stratified by state, race, and gender. Geographic, racial, and gender patterns were examined to assess disparities in mortality rates. Results: A total of 6,589 thyrotoxicosis-related deaths were identified. Racial disparities were evident, with Black or African American individuals exhibiting the highest AAMR (0.2 per 100,000), surpassing other racial groups. Geographic analysis revealed that the District of Columbia had the highest AAMR (0.3 per 100,000), followed by select Southern states. In contrast, certain regions reported significantly lower mortality rates. Gender analysis showed that mortality was higher among females (4,583 deaths) compared to males (2,006 deaths), reinforcing the well-documented higher prevalence and impact of thyroid disorders in women. Over time, a slight decline in mortality was observed, but disparities remained persistent. Conclusion: Significant geographic, racial, and gender disparities exist in thyrotoxicosis-related mortality. Black individuals, women, and residents of certain regions experience a disproportionate burden, underscoring the need for targeted interventions, improved healthcare access, and early detection initiatives. Addressing these disparities is crucial to reducing the mortality burden associated with thyrotoxicosis. Keywords: Thyrotoxicosis, mortality, disparities, geographic variations, racial disparities, gender disparities, CDC WONDER, epidemiology. Presentation: Monday, July 14, 2025