SUN-600 The Dual Burden of Diabetes and Hyperlipidemia: Untangling Mortality Trends and Disparities Among Adults in The United States (1999-2020)

Abstract Disclosure: H. Batool: None. R. Noor: None. S. Cheema: None. A. Dixit: None. S. Iftikhar: None. S. Sahu: None. T. Asghar: None. R. Ali: None. Introduction:With over 50% of diabetic patients being hyperlipidemic, it is a notable contributor of diabetes.We aimed to determine trends and disparities of mortality rates associated with hyperlipidemiaand diabetes in the United States (US) from 1999-2020 to identify and form targetedinterventions for the most vulnerable demographics. Methods: Using CDC WONDER data, we evaluated mortality rates for hyperlipidemia and diabetes inindividuals over 25+ in US. Sex, geography, race/ethnicity, states, location of death, andurbanization were the stratifications used to determine mortality rates. With statistical significance at p<0.05, we computed the crude mortality rates (CMR), age-adjusted mortalityrates (AAMR), annual percent change (APC), and average annual percent change (AAPC) with95% confidence Interval (95% CI). Results: Hyperlipidemia and diabetes accounted for 396540 fatalities in the US from 1999 to 2020. Therewas a significant sharp rise in the AAMR from 2.69 in 1999 to 6.52 in 2005 (APC: 16.00),followed by a significant steady rise from 6.52 in 2005 to 9.67 in 2013 (APC: 4.82), followed bya non-significant gradual rise from 9.67 in 2013 to 10.24 in 2018 (APC: 0.32). Ultimately asignificantly escalating upsurge was observed from 10.24 in 2018 to 14.7 in 2020 (APC:19.43)(AAPC: 8.11%, 95% CI: 7.59 to 9.07, p<0.000001). This trend was similar across genders. Menhad higher AAMRs than women (10.76 vs. 6.31) plus the rate of increase was also slightlyhigher for men (AAPC: 8.56) compared to women (AAPC: 7.70). The age group 85+ years hadthe highest CMR (65.78), followed by 75-84 years (39.29). When stratified by race, non-Hispanic (NH) American Indian or Alaska Natives had the highest AAMR (12.33), followed byNH Black or African American (10.77), Hispanic (9.43), NH Asian or Pacific Islander (8.14),and NH White (7.85). Across all races, AAMR saw a sharp increase after 2018, with the steepestrise observed in Hispanics (APC: 34.25). Geographically, the West was found to have thehighest AAMR (9.2), followed by Midwest (8.92), South (8.04), and lastly Northeast (6.82).Throughout the study period, non-Metropolitan had higher AAMR (9.40) than Metropolitan(8.01) while the states in top 90 percentile were Vermont (15.14), West Virginia (14.69), andHawaii (14.52) and Ohio (13.78). Majority of these fatalities occurred at the decedent’s home(39.54%) and medical facilities (38.92%). Conclusion: Mortality rates associated with diabetes and hyperlipidemia have escalated over the past twodecades, with a marked surge between 2018 and 2020. Marked disparities across demographicand regional groups emphasize the need for targeted strategies and legislative actions to combatthis growing mortality trend. Presentation: Sunday, July 13, 2025