OR17-08 Cross State Burden of Thyroid Cancer attributable to high BMI in the United States: Age, sex, regional disparities from 1990-2021

Abstract Disclosure: R. Daoud: None. A. Bhalodia: None. F.R. Viramgama: None. M. Nuthalapati: None. A. Dixit: None. T. Giri: None. A. Jamal: None. S. Goel: None. M. Chandra: None. V.P. Amin: None. H.D. Desai: None. Introduction: Deaths due to thyroid cancer (TC) in the USA represented 5.56% of all TC deaths globally, highlighting its significant impact. Obesity, a known risk factor, continues to pose a substantial health challenge in the USA, as it contributes to increasing cancer rates. While the association between high BMI (h-BMI) and TC is well-documented, comprehensive local and state-level data on disease burden is lacking. Method: Using standardized GBD study 2021 methodology, we estimated deaths, disability adjusted life years (DALYs), years lived with disability (YLDs) due to TC attributable to h-BMI by age, sex, year and location across the USA from 1990-2021. Results: 1990 to 2021, the annual percentage change (APC) in age-standardized mortality rate (ASMR) increased by 0.85%, while the age-standardized DALYs rate (ASDALR) rose by 0.89% (95% uncertainty interval: 0.87-0.91%), and the age-standardized YLDs rate (ASYLDR) increased by 1.72% (1.67-1.77%). At the state level, the highest increases in APC for ASMR were observed in Oklahoma (1.74%), West Virginia (1.65%), Kansas (1.59%), Arkansas (1.44%), Indiana (1.44%), Alabama (1.43%), New Mexico (1.41%), Iowa (1.41%), and Tennessee (1.39%), while the District of Columbia was the only state where a decrease was observed, at -0.31%, from 1990-2021. For ASYLDR, the highest increases were noted in New Mexico (2.77%), West Virginia (2.56%), Tennessee (2.38%), South Carolina (2.26%), Georgia (2.21%), Mississippi (2.19%), and Arkansas (2.18%), with the lowest increase in New Jersey (0.90%). Age-wise, the highest APCs in total number of deaths were observed in the 95+ age group (6.11%), followed by the 90-94 years (4.76%), 85-89 years (3.44%), 70-74 years (3.14%), 80-84 years (2.93%), 75-79 years (2.76%), and 60-64 years (2.62%). For YLDs, the highest rates were in the 95+ years (6.51%), 90-94 years (5.07%), 85-89 years (4.48%), 70-74 years (4.14%), 80-84 years (3.80%), and 60-64 years (3.73%). In terms of gender, males have observed an increase in the overall burden compared to females over the past 3 decades, with APCs in ASMR, ASDALR, and ASYLDR for males vs females being 1.08% vs 0.67%, 0.96% vs 0.84%, and 1.74% vs 1.74%, respectively, from 1990 to 2021. Conclusion: Deaths due to TC attributable to h-BMI accounted for 17.15% of all TC causes. This study reveals a significant escalation in the burden of TC attributable to high BMI from 1990-2021, particularly affecting older age groups and males more severely, with notable regional disparities in the USA. These findings emphasize the critical need for targeted public health strategies to combat obesity, a major risk factor for TC. Future directions should focus on community-based interventions to promote healthier lifestyles and enhance screening programs, aiming to manage and mitigate the rising incidence of TC effectively and reduce its impact on at-risk populations. Presentation: Sunday, July 13, 2025