Proposal of a management algorithm for delayed neurological syndrome following carbon monoxide poisoning.

Delayed encephalopathy or post-interval syndrome can develop some time after acute carbon monoxide (CO) poisoning and its hyperbaric treatment. The clinical presentation is highly heterogeneous and variable, and this syndrome is often underdiagnosed. Although there are no definitive predictive markers, several risk factors have been identified that may predispose individuals to its development. Post-interval syndrome is relatively un- known among healthcare professionals and should be considered in all CO-poisoned patients who develop neu- rological symptoms after a symptom-free interval. Proper training of healthcare providers and the imple- mentation of standardized operational protocols are es- sential.