Paraneoplastic cerebellar degeneration secondary to occult invasive lobular carcinoma of the breast

We report a rare case of paraneoplastic cerebellar degeneration (PCD) secondary to an occult invasive lobular breast carcinoma. The patient presented with rapidly progressive cerebellar symptoms and was found to have anti-Zic4 antibodies, an association uncommon in breast cancer. This case underscores the diagnostic challenge of PCD and highlights the importance of considering paraneoplastic causes in unexplained neurological decline. Keywords:Paraneoplastic cerebellar degeneration, breast cancer, anti-Zic4 antibodies, neurology, case report

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-05-23
DOI
https://doi.org/10.5281/zenodo.17397094
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Paraneoplastic cerebellar degeneration secondary to occult invasive lobular carcinoma of the breast

Zenodo (CERN European Organization for Nuclear Research)
Autoimmune Neurological Disorders and Treatments
article

Paraneoplastic cerebellar degeneration secondary to occult invasive lobular carcinoma of the breast

article en

Abstract

We report a rare case of paraneoplastic cerebellar degeneration (PCD) secondary to an occult invasive lobular breast carcinoma. The patient presented with rapidly progressive cerebellar symptoms and was found to have anti-Zic4 antibodies, an association uncommon in breast cancer. This case underscores the diagnostic challenge of PCD and highlights the importance of considering paraneoplastic causes in unexplained neurological decline. Keywords:Paraneoplastic cerebellar degeneration, breast cancer, anti-Zic4 antibodies, neurology, case report

Zenodo (CERN European Organization for Nuclear Research)
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Autoimmune Neurological Disorders and Treatments
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Paraneoplastic cerebellar degeneration secondary to occult invasive lobular carcinoma of the breast · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS