Nickel-catalyzed C(sp <sup>2</sup> )–H bond aminoalkylation of alkenes and arenes for the synthesis of δ-amino acid derivatives

Efficient Ni-catalyzed C(sp 2 )-H aminoalkylation enables chiral amine synthesis with facile operation, accessible building blocks, and retained stereochemistry, advancing drug late-stage diversification.

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Publication Details

Journal
Organic Chemistry Frontiers
Published
2025-10-21
DOI
https://doi.org/10.1039/d5qo01273b
Primary Topic
Catalytic C–H Functionalization Methods
Type
article
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article

Nickel-catalyzed C(sp 2 )–H bond aminoalkylation of alkenes and arenes for the synthesis of δ-amino acid derivatives

Organic Chemistry Frontiers
Catalytic C–H Functionalization Methods
article

Nickel-catalyzed C(sp 2 )–H bond aminoalkylation of alkenes and arenes for the synthesis of δ-amino acid derivatives

article en

Abstract

Efficient Ni-catalyzed C(sp 2 )-H aminoalkylation enables chiral amine synthesis with facile operation, accessible building blocks, and retained stereochemistry, advancing drug late-stage diversification.

Organic Chemistry FrontiersVol. 13(1)
Nanjing Tech University (CN), Northwestern Polytechnical University (CN), Nanyang Technological University (SG)
Openalex Percentile: Top 45%
Catalytic C–H Functionalization Methods
DOISourceOpenAlex
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Nickel-catalyzed C(sp <sup>2</sup> )–H bond aminoalkylation of alkenes and arenes for the synthesis of δ-amino acid derivatives · Organic Chemistry Frontiers (2025) | TGRS Research Map | TGRS