Pharmacological Evaluation of Delonix regia Extract on Clozapine-Induced Body Weight Gain and Lipid Metabolism in SD Female Rats.

Abstract:Second-generation antipsychotics like Clozapine are frequently used to treat bipolardisorder and schizophrenia, but they also have serious metabolic side effects include weight gainand dyslipidemia. The purpose of this study is to assess the pharmacological potential of Delonixregia (DLR) extract in reducing lipid abnormalities and body weight gain caused by Clozapinein female Sprague-Dawley (SD) rats.A total of five groups of female rats were randomlyassigned: control, Clozapine treated, Clozapine + DLR extract-treated, . For 21 days, theDelonix regia extract was given orally at a dose of 100,200 and 400 mg/kg/day, whereasclozapine was given at a dose of 2 mg/kg/day. Periodically, measurements were made of bodyweight, food consumption, and lipid profile parameters (total cholesterol, triglycerides, HDL,and LDL). Hepatic lipid buildup was also evaluated by histopathologically analyzing livertissue.In comparison to the clozapine -only group, the results showed that co-administration ofDLR extract significantly decreased clozapine -induced weight gain and improved serum lipidprofiles. Histological results confirmed that Delonix regia had a protective impact on livermorphology. According to these results, Delonix regia may present a viable herbal remedy tolessen the metabolic side effects brought on by antipsychotics, therefore improving the long-termsafety profile of clozapine treatment.