The effect of Temulawak extract ( Curcuma xanthorrhiza roxb .) On serum albumin in Wistar Rats induced by Paracetamol

Introduction: Paracetamol is a drug that is often used as an analgesic and antipyretic. However, the incidence of poisoning due to Paracetamol is still relatively high. Liver damage due to a lethal dose of Paracetamol causes an increase in liver serum enzymes and a decrease in albumin levels. Various plants have been extensively researched to act as hepatoprotectors. Temulawak (Curcuma xanthorrhiza) contains secondary metabolites, including xanthorrhizol and curcumin, which function as hepatoprotection by capturing free radicals, lipid peroxidase, and reducing hepatocyte apoptosis.Objective: This study aims to determine the effect of ginger extract on serum albumin levels induced by Paracetamol in Wistar rats.Methods: This research is an experimental study (pretest-posttest with control group). A total of 25 rats were divided into five groups: Group I (K1) was only given distilled water; Group II (K2) was given Paracetamol 2000 mg/kg BW; Group III (P1) given 800 mg/kgBW ginger extract on days 8-14 and Paracetamol 2000 mg/kgBW on day 19-21 for three days; Group IV (P2) given ginger extract 1600 mg/kgBW on day 8-14 and Paracetamol 2000 mg/kgBW on day 19-21 for three days; and group V (P3) given ginger extract 3200 mg/kgBW on day 8-14 and Paracetamol 2000 mg/kgBW on days 19-21 for three days. Serum albumin levels were measured before and after treatment.Results: Temulawak extract at 1600 and 3200 mg/kgBW had a better hepatoprotective effect than 800 mg/kgBW. Statistically, the difference is significant with a p=0.000 (p0.05).Conclusion: Ginger extract has a significant effect on changes in serum albumin levels in Wistar rats induced by toxic doses of Paracetamol.