METHOD DEVELOPMENT AND METHOD VALIDATION OF CEFTAZIDIME AND AVIBACTAM BY RP-HPLC

Using a Waters PDA-detected HPLC mode and a quick, sensitive, and precise RP-HPLC approach, Avibactam and Ceftazidime have been identified and quantified. An Inertsil-ODS C18 (250 x 4.6 mm, 5) column was used to separate Avibactam and Ceftazidime at a volumetric rate of 1.0 ml/min. The filtered mobile phase of the process was combined with degassed Methanol and Acetonitrile (70:30), and the wavelength of detection was 275 nm.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-10-15
DOI
https://doi.org/10.5281/zenodo.17365279
Primary Topic
Antibiotics Pharmacokinetics and Efficacy
Type
article
Field-Weighted Citation Impact
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article

METHOD DEVELOPMENT AND METHOD VALIDATION OF CEFTAZIDIME AND AVIBACTAM BY RP-HPLC

Zenodo (CERN European Organization for Nuclear Research)
Antibiotics Pharmacokinetics and Efficacy
article

METHOD DEVELOPMENT AND METHOD VALIDATION OF CEFTAZIDIME AND AVIBACTAM BY RP-HPLC

article en

Abstract

Using a Waters PDA-detected HPLC mode and a quick, sensitive, and precise RP-HPLC approach, Avibactam and Ceftazidime have been identified and quantified. An Inertsil-ODS C18 (250 x 4.6 mm, 5) column was used to separate Avibactam and Ceftazidime at a volumetric rate of 1.0 ml/min. The filtered mobile phase of the process was combined with degassed Methanol and Acetonitrile (70:30), and the wavelength of detection was 275 nm.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 38%
Antibiotics Pharmacokinetics and Efficacy
DOIOpen Access PDFOpenAlex
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METHOD DEVELOPMENT AND METHOD VALIDATION OF CEFTAZIDIME AND AVIBACTAM BY RP-HPLC · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS