Proton pump inhibitor-induced suboptimal response to levothyroxine: A primary care case report

Levothyroxine is commonly prescribed in primary care for hypothyroidism patients. Its absorption may be reduced significantly by concurrent medications, especially proton pump inhibitors (PPIs).[1,2] This case report represents a practical example of reduced levothyroxine efficacy due to omeprazole use and highlights key learning points for primary care clinicians.