DEVELOPMENT AND OPTIMIZATION OF FLIBANSERIN 100 MG FILM-COATED TABLETS USING WET GRANULATION TECHNIQUE

Flibanserin is a centrally acting serotonin receptor modulator indicated for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. Due to its poor aqueous solubility and limited bioavailability, formulation development poses significant challenges. The present study aimed to develop and optimize a 100 mg film-coated tablet formulation of Flibanserin using the wet granulation method to ensure uniformity, stability, and compliance with pharmacopeial quality standards.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-10-16
DOI
https://doi.org/10.5281/zenodo.17369541
Primary Topic
Drug Solubulity and Delivery Systems
Type
article
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article

DEVELOPMENT AND OPTIMIZATION OF FLIBANSERIN 100 MG FILM-COATED TABLETS USING WET GRANULATION TECHNIQUE

Zenodo (CERN European Organization for Nuclear Research)
Drug Solubulity and Delivery Systems
article

DEVELOPMENT AND OPTIMIZATION OF FLIBANSERIN 100 MG FILM-COATED TABLETS USING WET GRANULATION TECHNIQUE

article en

Abstract

Flibanserin is a centrally acting serotonin receptor modulator indicated for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. Due to its poor aqueous solubility and limited bioavailability, formulation development poses significant challenges. The present study aimed to develop and optimize a 100 mg film-coated tablet formulation of Flibanserin using the wet granulation method to ensure uniformity, stability, and compliance with pharmacopeial quality standards.

Zenodo (CERN European Organization for Nuclear Research)
Istanbul Commerce University (TR)
No poverty
Openalex Percentile: Top 52%
Drug Solubulity and Delivery Systems
DOIOpen Access PDFOpenAlex
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DEVELOPMENT AND OPTIMIZATION OF FLIBANSERIN 100 MG FILM-COATED TABLETS USING WET GRANULATION TECHNIQUE · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS