SUNSCREEN PROTECTION AGAINST UV LIGHT

Octyl methoxycinnamate (OMC) is one of the most widely used Sunscreen ingredients. To analyze biological effects of OMC, an In vitro approach was used implying ultraviolet (UV) exposure of Two human cell lines, a primary skin fibroblast (GM00498) and A breast cancer (MCF-7) cell lines The absorption properties, safety, photostability of different organic and inorganic filters are reviewed: para-aminobenzoic acid, salicylates, cinnamates, benzophenones, butylmethoxydibenzoylmethane (Parsol 1789), drometrizole trisulphonic (Mexoryl XL), terephthalydene dicamphor sulphonic acid (Mexoryl SX), methylene bisbenzotriazol tetramethylbutylphenol (Tinasorb M), anisotriazine (Tinasorb S), titanium dioxide and zinc oxide. Half of all cancers in the United States are skin cancers. We have previously shown in a 4.5-year randomized controlled trial in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular sunscreen application to the head, neck, hands, and forearms. One approach to protecting human skin against the harmful effects of UV irradiation is to use antioxidants as Photoprotective. In recent years naturally occurring herbal compounds such as phenolic acids, flavonoids, and high molecular weight polyphenols have gained considerable attention as beneficial protective agents.