Evaluation of Effect of Chronic Unpredictable Mild Stress on Albino Rats WSR To Hematology Parameters

Abstract During the past three decades the number of deaths due to CVDs has increased from 15.2% to 28.1% in India. There are many dietary and lifestyle factors are responsible for this rise. In the common aetiology of heart diseases stated by acharya Charaka, along with other causes, psychological causes like Chinta (worry), Bhaya (Fear/Anxiety), manasik trass (mental tension) are mentioned as factors responsible for heart disease. There is sharp increase in cases of anxiety and depression due to change lifestyle in present era. Hence, it is essential to evaluate the role of Ayurvedokta psychological factor such as Bhaya (Anxiety) in the development of heart disease. Chronic unpredictable mild stress (CUMS) is the most elegant model for evaluation of anxiety in the rats as this model possesses construct, predictive and face validity in rats. Hence, this model is used in the present study. In CUMS process, animals will be subjected chronically and unpredictably to a variety of low-grade stressors which resembles to those associated with anxiety like symptoms in humans and also cause cognition impairment. It is observed that CUMS had generated the anxiety in rats leading to alteration in normal cardiac physiology. Keywords – Manasik trass, Bhaya (Anxiety), Hematology Parameters, CVDs