Comparison OF IV Dexmedetomidine and IV Esmolol for Suppression of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

Background: Direct laryngoscopy and endotracheal intubation are almost always associated with hemodynamic changes such as hypertension, tachycardia and arrhythmias[1,8,13].The purpose of our study was to compare intravenous Dexmedetomidine(1mcg/kg) and intravenous Esmolol(1.5 mg/kg) for suppression of hemodynamic responses secondary to laryngoscopy and endotracheal intubation. Material and methods: This was a comparative, observational, and prospective study in which total 60 patients undergoing elective surgery under general anaesthesia were divided into two equal groups. Group-D received inj. Dexmedetomidine 1 mcg/kg IV infusion (diluted to 10 ml with normal saline) over 10 minutes before induction Group E: Patients who received Injection Esmolol 1.5 mg/Kg IV (diluted to 10 ml with normal saline) 2 minutes before induction. Baseline preoperative values of hemodynamic parameters were recorded. Both groups were observed for Changes in HR,SBP,DBP,MAP and Spo2,After study drug, After induction, Immediately after intubation,At 1 min, 3 min, 5 min, 7 min, 10 min after Intubation and Patients were observed for any adverse effects and treated accordingly. Result:From the observation it was found that Dexmedetomidine had better attenuation of the stress response during laryngoscopy and intubation than Esmolol. However, there was no significant difference in hemodynamic parameters after study drug and after induction,there was highly significant difference between two groups immediately after intubation and 1,3,5,7,10 min after intubation. Conclusion: Dexmedetomidine 1 mcg/kg IV was more effective in attenuating the hemodynamic stress response to laryngoscopy and intubation, provides more hemodynamic stability as compared Esmolol 1.5 mg/kg IV.