Front Cover: Therapeutic Oligonucleotides for Neurodegenerative Diseases: Aptamer Strategies and Clay Nanoparticle‐Based Delivery (Chem. Rec. 10/2025)

The cover illustrates G-quadruplex-forming aptamers as therapeutic oligonucleotides for neurodegenerative diseases. Their unique secondary structures confer high target specificity, while clay-based nanocarriers, including halloysite nanotubes and montmorillonite, are depicted as stabilizing and delivery platforms. This combination provides exciting opportunities to enhance nuclease resistance, bioavailability, and targeted transport across biological barriers. More details can be found in the Review by Bruno Pagano and co-workers (DOI: 10.1002/tcr.202500126).