Analysis of Three Market Samples of Triphala Guggulu w.s.r. to its Hardness, Disintegration, and Dissolution Test

Abstract Background: Triphala Guggulu is a classical Ayurvedic formulation widely used for metabolic disorders, inflammation, and gastrointestinal ailments. Ensuring its quality, safety, and efficacy requires rigorous pharmaceutical evaluation. Among various parameters, hardness, disintegration, and dissolution play a critical role in determining bioavailability and therapeutic consistency. Aim: To analyze three marketed samples of Triphala Guggulu with respect to hardness, disintegration, and dissolution, thereby evaluating pharmaceutical quality compliance.Methodology: Three coded market samples of Triphala Guggulu were subjected to pharmacopoeial evaluation. Hardness was determined using a Monsanto hardness tester. Disintegration test was performed in distilled water at 37 ± 2 °C using a standard disintegration apparatus. Dissolution studies were carried out using USP apparatus II (paddle method) in simulated gastric fluid, with absorbance readings taken spectrophotometrically. Results: Variation was observed among the three samples. Hardness values differed, indicating inconsistency in compression force and excipient use. Disintegration time varied, with one sample complying with Ayurvedic Pharmacopoeia standards, while others exceeded permissible limits. Dissolution profiles revealed marked differences, reflecting the influence of formulation and processing methods on drug release. Conclusion: Considerable inter-brand variation exists in hardness, disintegration, and dissolution of marketed Triphala Guggulu formulations. This highlights the need for stringent quality standardization, uniform manufacturing practices, and strict regulatory monitoring to ensure therapeutic reliability and consumer safety. Keywords – Triphala Guggulu, Hardness, Disintegration, Dissolution, Quality Control, Ayurvedic Formulations