Clinical and Functional outcome after local injection of autologous platelet rich plasma in symptomatic Rotator cuff tendinopathy

Introduction: Rotator cuff tendinopathy (RCT) is a leading cause of shoulder pain, significantly impairing daily function. Platelet-rich plasma (PRP), rich in growth factors, has emerged as a potential regenerative therapy. This study evaluates the efficacy of autologous PRP in symptomatic RCT unresponsive to conservative treatment. Methods: A prospective cohort study of 30 patients with MRI-confirmed RCT was conducted. Patients received a single intra-articular PRP injection under aseptic conditions. Functional and pain outcomes were assessed using DASH, SPADI, and VAS scores at baseline, 4, 12, and 24 weeks. Results: Significant improvement was observed in all outcome measures over 6 months. Mean DASH decreased from 63.1 to 36.4, SPADI from 67.2 to 34.6, and VAS from 5.4 to 1.5 (p < 0.001). No serious adverse events were reported. Conclusion: Autologous PRP is a safe and effective treatment for RCT, offering meaningful pain relief and functional recovery. Further randomized studies with standardized protocols are warranted.