TARGET-CONTROLLED INFUSION VERSUS INTERMITTENT BOLUS ADMINISTRATION OF PROPOFOL FOR SEDATION IN COLONOSCOPY: A RANDOMIZED CONTROLLED TRIAL

Background: Propofol is the preferred sedative agent for colonoscopy, but optimal administration techniques remain debated. This study compared target-controlled infusion (TCI) with intermittent bolus (IB) administration regarding safety, enjcacy, and patient satisfaction. Methods:We conducted a prospective, randomized, single-center study of 100 patients (ASA I-III) undergoing elective colonoscopy. Patients were randomized to receive propofol via TCI (n=50) or IB administration (n=50). Primary endpoints included composite safety outcomes and sedation adjustments. Secondary endpoints comprised propofol consumption, recovery time, and satisfaction scores. Conclusion: Both techniques demonstrated comparable overall safety. TCI provided superior sedation stability and patient satisfaction but required higher drug consumption and longer recovery times.Technique selection should be individualized based on patient characteristics and clinical priorities.