Advances in quality assessment and analytical techniques for losartan potassium: A comprehensive review

Losartan Potassium, a medication that blocks angiotensin II receptors, is commonly prescribed for managing high blood pressure and kidney issues in diabetic patients. Monitoring its quality and therapeutic performance is essential, especially due to concerns about inconsistent bioavailability and the presence of harmful nitrosamine contaminants. This review provides a critical evaluation of the physicochemical, spectrophotometric, and chromatographic methods used to assess the quality and purity of Losartan Potassium. The study highlights gaps in current methodologies and underscores the need for more robust analytical approaches, such as HPTLC-MS, to improve detection and quality assurance.