ANALYSIS OF THE ROLE AND SIGNIFICANCE OF DRUGS ACTING ON CHOLINERGIC RECEPTORS IN MEDICAL PRACTICE

All of the body's organs and tissues have muscarinic acetylcholine (ACh) receptors, commonly referred to as M receptors. These receptors primarily function in cholinergic nerve conduction. Although there are five distinct subtypes of muscarinic ACh receptors, it is still unclear how each of them affects cardiac function pharmacologically. Muscarinic ACh receptors may have an impact on functional myocardial disorders and myocardial traumas, including arrhythmia, myocardial ischemia, myocarditis, and myocardial fibrosis. In order to develop better strategies and provide references for further revealing and clarifying the signal transduction and mechanisms of muscarinic ACh receptors in cardiomyocytes, as well as to identify potential myocardial protective drugs that act on muscarinic ACh receptors, this article reviews the research progress on the regulation of myocardial function by muscarinic ACh receptors and related diseases.