Synthesis of aminoalkyl nitriles through 2-azaallyl-anion-driven cascade radical ring-opening/intermolecular coupling

A novel tandem SET/radical ring-opening/coupling between 2-azaallyl anions and O -aryl oxime ethers provides aminoalkyl nitriles under mild conditions. The gram-scale sequential synthesis and hydrolysis demonstrated the scalability of the chemistry.

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Publication Details

Journal
Organic Chemistry Frontiers
Published
2025-10-16
DOI
https://doi.org/10.1039/d5qo01353d
Primary Topic
Diffusion and Search Dynamics
Type
article
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article

Synthesis of aminoalkyl nitriles through 2-azaallyl-anion-driven cascade radical ring-opening/intermolecular coupling

Organic Chemistry Frontiers
Diffusion and Search Dynamics
article

Synthesis of aminoalkyl nitriles through 2-azaallyl-anion-driven cascade radical ring-opening/intermolecular coupling

article en

Abstract

A novel tandem SET/radical ring-opening/coupling between 2-azaallyl anions and O -aryl oxime ethers provides aminoalkyl nitriles under mild conditions. The gram-scale sequential synthesis and hydrolysis demonstrated the scalability of the chemistry.

Organic Chemistry FrontiersVol. 13(2)
Yunnan University (CN), Southwest Forestry University (CN), Baoshan University (CN)
Openalex Percentile: Top 44%
Diffusion and Search Dynamics
DOISourceOpenAlex
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Synthesis of aminoalkyl nitriles through 2-azaallyl-anion-driven cascade radical ring-opening/intermolecular coupling · Organic Chemistry Frontiers (2025) | TGRS Research Map | TGRS