Clinical profile and outcome of Acute Kidney Injury in COVID-19 patients hospitalised at Tertiary care centre

Background: Initial reports suggested that incidence of Acute Kidney Injury (AKI) in COVID-19 positive patients was less. However with time, we found that evidence of AKI among patients with COVID-19, was significantly more particularly in intensive care unit (ICU) patients. New York City health system admitted total 3993 COVID -19 patients. Out of which AKI occurred in 1835 (46%) patients. From them 19% patients required dialysis treatment and 50 % of them died in hospital during treatment. Out of which 35% did not recover their creatinine level to baseline at the time of discharge. However, according to Indian data available, overall incidence of AKI is 5.1%.Data on AKI is insufficient as initial reporting incidence is on basis of case series and retrospective studies. AKI can be a severe complication of COVID-19 and hence we wish to assess, define and report the course of AKI in patients with COVID-19. Incidence of AKI may vary with age, severity of disease, comorbid conditions and ethnicity of patients .The pathogenesis of AKI in COVID-19 is through many mechanisms rather than one. Study of AKI in COVID-19 in depth is necessary to know and draw conclusions. Materials and Methods: Descriptive observational Retrospective and Prospective Cohort study was done on 200 patient admitted in medicine department. RTPCR positive COVID-19 patients with age more than 18 years included in study .All necessary clinical data collected from patient records. Results: Incidence of AKI in COVID-19 was 71% in hospitalised patients. AKI is more in elder patients, those having comorbid conditions. Mortality rate is more inpatients having AKI.73.6% of patient’s serum creatinine did not return to base level. Conclusion: This study indicate that AKI frequently complicates COVID-19 . There is high mortality rate in patients with COVID -19 AKI and lower rate of recovery of renal function .Early detection of comorbidities and kidney outcomes is essential to improve outcomes in COVID-19.Assessing, defining, and reporting the course of AKI in COVID-19 patients becomes crucial.