To Study the Clinical Profile, Causes and Outcome of Thrompocytopenia in Neonates Admitted In Tertiary Care Hospital

Background: Thrombocytopenia is one of the most common hematological abnormalities in newborns. It occurs mainly in preterm or sick neonates and is caused by decreased platelet production or increased platelet consumption. Aim: To study the clinical profile, causes and outcome of thrombocytopenia in neonates admitted in Tertiary Care Hospital. Methods: A profile of 150 consecutive neonates admitted to the NICU’s in Postgraduate department of Pediatrics, G.B pant General Hospital over a period of 2 years (October 2018 to November 2020) irrespective of their underlying morbidity were taken up for the study. All the neonates, except who were lost for follow up and those who expired, were followed up after their discharge once in a period of 6 months. Results: The most common maternal risk factor was anaemia which was present in 72 (48%) babies and association of anaemia with severe neonatal thrombocytopenia was statistically significant (P value <0.05). Early onset neonatal thrombocytopenia was more common, and it was associated with mild to moderate neonatal thrombocytopenia. Sepsis was the commonest cause of neonatal thrombocytopenia and was found in 79 (52.7 %) babies. PT INR, appt was done in 54 and it was abnormal in 26 (48.14 %) babies. This was statically significant. The mortality was significantly high in severe thrombocytopenia group (46.7%) as compared to other 2 groups and it was not statistically significant. Conclusion: Our study concludes that, severe thrombocytopenia can be used as a prognostic indicator in sick neonates. But to generalize this statement, and apply to all neonatal admissions, more studies are required in this regard with similar results.