FORMULATION DEVELOPMENT OF CHITOSAN GELS ENRICHED WITH VANCOMYCIN HCL SOLID LIPID NANOPARTICLES

The present study was aimed at the formulation and development of chitosan-based gels incorporated with Vancomycin HCl-loaded solid lipid nanoparticles (SLNs) for enhanced topical delivery. Vancomycin HCl, a potent glycopeptide antibiotic, was encapsulated into SLNs to improve its stability and controlled release profile. These SLNs were subsequently integrated into a chitosan gel matrix to facilitate effective topical application. The formulations were evaluated for particle size, zeta potential, entrapment efficiency, pH, viscosity, spreadability, drug content, and in vitro drug release. The optimized formulation exhibited desirable physicochemical properties, high drug encapsulation, and sustained drug release, making it suitable for localized treatment of bacterial infections. The study concludes that chitosan gels enriched with Vancomycin HCl SLNs provide a promising and effective strategy for the topical delivery of antibiotics with improved therapeutic outcomes and patient compliance. Keywords: Vancomycin HCl, chitosan-based gels