FORMULATION AND EVALUATION OF NANOSUSPENSION DRUG DELIVERY SYSTEM OF FLUCONAZOLE PRODUCED BY NANOPRECIPITATION METHOD

The present research aimed to develop & Evaluation of Fluconazole Nanosuspension. Fluconazole is a medication used to treat fungal infections. The formulated Nanosuspension was subjected to various evaluation parameters like particle size, polydispersity index, zeta potential, drug content, saturation solubility studies, In vitro release studies. The polydispersity ranged from 0.40 PDI to 1.36 PDI and zeta potential ranged from -17.51 mV to -35.42 mV are the important evaluation parameters are responsible for the stability of nanosuspensions. In this result, F3 formulation shows spectacular drug content range of 76.89 % to 98.97 % it is the maximum drug content. Fourier transform infrared spectroscopy indicated that there was no possible interaction between drug and polymer. In dissolution studies F3 formulation showed maximum drug release compared with other formulation. Hence F3 formulation was considered as optimised formulation. From this study, it was concluded that in recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance, one such approach is Nanosuspension. Keywords: Fluconazole, Carbopol, Ethyl Cellulose, Na CMC and Nanosuspension.