Design, Characterization and Optimization of Fast Dispersible Herbal Tablet Containing Ashwagandha, Amla and Ginger

Background: In the ever-changing world of Pharmaceutics, continuous modern inventions are crucial for the improvement in patient compliance, stability and efficacy of formulations. Aim: Thus, attempt was made to optimize the formulation of a fast-dissolving herbal tablet, containing the extracts of Ashwagandha, Amla and Ginger. Method: Direct compression method was employed for formulation of herbal tablet by mixing suitable excipients and herbal drugs. The independent variables chosen were croscarmellose sodium (CCS) and sodium starch glycolate (SSG). Dependent variables that were tested upon the formulations were hardness and dispersion time. Results: Average weight of the formulated tablet was 318.43mg and dispersion time was found to be 58.7 seconds. Attenuated total reflectance infrared (ATR-IR) spectroscopy revealed that there were no major interactions between the excipients and the herbal drugs. The average particle size was calculated from XRD data using Scherrer Equation which was found to be 7.956 nm. The microstructure of formulated herbal tablet was observed using field emission scanning electron microscopy (FE-SEM) imaging, which also showed that the herbal constituents were homogeneously distributed throughout the herbal tablet. Antioxidant study showed good radical scavenging activity (% RSA) reaching up to 95.77%. Conclusion: Qualitative and quantitative HPTLC showed that the herbal components were sufficiently incorporated in the formulations.