Contemporary application and prospects of mesenchymal stem cell therapies in gynecology and gynecologic oncology

Dear Editor, Mesenchymal stem cells (MSCs) have garnered increasing interest because to their multidirectional differentiation potential, immunomodulatory capabilities, and self-renewal capacity. Being able to comprehend the multi-omics molecular background of stem cells has the potential to offer us with important information on the treatment of diseases, including gynecological disorders, as well as the synthesis of healthy cells for use in regenerative medicine. Due to the fact that they encourage immunoregulatory, anti-inflammatory, anti-apoptotic, and anti-oxidative activities, MSCs have been proven to possess paracrine capabilities. This gives them the status of agents that are tolerant of the immune system. In addition, they possess both pain-relieving and angiogenic actions (1). A significant number of findings concerning mesenchymal stem cells have been made in a variety of medical fields, and a great deal of research has been published on the therapeutic potential of these cells. For instance, in specialties of medicine such as psychiatry and general surgery, their efficiency in the treatment of disorders is becoming more and more evident (2-4). This letter is written with the intention of bringing attention to the vast number of studies that have been conducted in aspects of gynecology, and gynecologic oncology, as well as the utilization of mesenchymal stem cells in these areas (5-7).