Gastric Peroral Endoscopic Myotomy in a Patient with Long-Standing Gastroparesis.

Abstract: Gastroparesis is a chronic motility disorder characterized by slow gastric emptying. It causes unpleasant symptoms that results in poor quality of life. Current treatments include symptomatic management with antiemetics and prokinetic medications, surgical treatment through pyloric myotomy, surgical pyloroplasty, gastric pacemaker, and endoscopic treatments like pyloric injection of botulinum toxin, transpyloric stents, and gastric peroral endoscopic myotomy (G-POEM). Metoclopramide is the only medicine approved by U.S. Food and Drug administration for gastroparesis and it can cause serious side effects. G-POEM is an advanced, minimally invasive endoscopic intervention for the treatment of gastroparesis. This procedure has demonstrated noteworthy improvements in symptoms and is now considered the preferred approach for permanent treatment of gastroparesis. This article discusses the case of gastroparesis in a 67-year-old female who was treated by G-POEM, which subsequently resulted in a significant reduction in her gastroparesis cardinal symptom index (GCSI) score and resolution of most of her symptoms. Keywords: gastric peroral endoscopic myotomy (G-POEM), gastroparesis cardinal symptom index (GCSI)