H-ABC tubulinopathy exhibits a cytoskeletal defect associated with microtubule stability

This dataset supports the study exploring the molecular mechanisms underlying hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC), a tubulinopathy caused by mutations in TUBB4A. Using the taiep rat, a spontaneous model of the disease, we performed immunostaining on the cerebellum and corpus callosum to analyze post-translational modifications (PTMs) of tubulin, including acetylation, phosphorylation, and detyrosination. In addition, the dataset includes confocal images from HeLa cells and the oligodendrocyte cell line MO3.13 treated with paclitaxel, allowing comparisons between microtubule stability and microtubule defect in the tubulinopathy H-ABC.