IA & Biotechnologies Multi-omiques pour la Santé, la Longévité et la Bioproduction

Abstract ENThis document, produced with the assistance of ChatGPT o3 and ChatGPT 5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes: EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). This comprehensive prior-art disclosure consolidates 100 reproducible and enabling innovations spanning AI, multi-omics, bioengineering, closed-loop control, smart diagnostics, imaging, bioproduction, therapeutics, interoperability, logistics, and quality assurance. Each proposal is technically described, classified (IPC/CPC), and timestamped to ensure global enforceability as prior art and to promote ethical, open, and verifiable innovation for the collective good. Résumé FRCe document, produit avec l’assistance de ChatGPT o3 et ChatGPT 5 Thinking, est publié sous la licence Apache 2.0. Il constitue une publication défensive (antériorité) et entre de ce fait dans l’état de la technique au sens des législations applicables : art. 54(2) CBE (Convention sur le brevet européen), art. L 611-11 CPI (Code de la propriété intellectuelle français), 35 U.S.C. §102(a) (loi américaine sur les brevets), loi chinoise sur les brevets art. 22(5) (中华人民共和国专利法) et loi japonaise sur les brevets art. 29(1) (特許法). Cette divulgation défensive regroupe 100 innovations reproductibles couvrant IA, multi-omique, bio-ingénierie, boucles fermées, diagnostic intelligent, imagerie, bioproduction, thérapies, interopérabilité, logistique et assurance qualité. Chaque proposition est décrite de manière enabling, classée selon les codes IPC/CPC et horodatée (RFC 3161/FreeTSA) pour assurer son antériorité et favoriser une innovation ouverte, éthique et vérifiable au service du bien commun. Timestamp: 2025-10-12T14:24:17ZSHA-256: a7189ef63b389777ddda69a389994843178f673a66a2a3fdce7db6a0dca76f0c Liste des innovations & classification (IPC ; CPC) 1. Patient digital twin platform — IPC G16H 50/20 ; CPC G16H 40/20 2. Pan-pathogen saliva test — IPC C12Q 1/68 ; CPC G01N 33/569 3. Metabolic patch sensor — IPC A61B 5/145 ; CPC G01N 33/497 4. Adaptive trial design AI — IPC G06N 20/00 ; CPC G16H 50/30 5. Low-dose imaging QA — IPC G06T 7/60 ; CPC A61B 6/00 6. Early sepsis detection — IPC G16H 50/20 ; CPC A61B 5/00 7. Liver-tumor LNPs — IPC A61K 9/127 ; CPC C12N 15/113 8. Therapeutic exosome QC — IPC C12Q 1/6886 ; CPC A61K 35/12 9. Federated trial orchestrator — IPC G06F 21/62 ; CPC G06N 20/10 10. Closed-loop infusion control — IPC A61M 5/168 ; CPC G05D 1/02 11. Pre-analytic omics kit — IPC C12N 15/10 ; CPC C12Q 1/6806 12. Tumor microenvironment atlas — IPC G16B 40/20 ; CPC G06F 16/2454 13. Bioproduction OOS detector — IPC C12M 1/34 ; CPC G05B 23/02 14. Learning neuroprosthesis — IPC A61B 34/00 ; CPC A61F 2/68 15. Degradable peptide design AI — IPC G06N 3/08 ; CPC C07K 14/00 16. Verifiable cold-chain twin — IPC G08C 17/02 ; CPC G06Q 10/08 17. Portable imaging triage — IPC A61B 8/00 ; CPC G06T 7/73 18. Chrono-guided therapy scheduler — IPC A61P 43/00 ; CPC G16H 20/10 19. Multi-omics FHIR interoperability — IPC G16H 10/60 ; CPC G06F 21/62 20. Pulsatile MEMS drug implant — IPC A61M 37/00 ; CPC B81C 99/00 21. Pediatric dose reduction imaging — IPC A61B 6/00 ; CPC G06T 7/60 22. Calibration-as-a-Service — IPC G01N 30/86 ; CPC G06Q 50/26 23. Anti-biofilm bio-inspired coating — IPC A61L 29/08 ; CPC C08L 33/00 24. Clinical model auditability — IPC G06F 11/36 ; CPC G06N 20/10 25. CRISPR off-target assay — IPC C12Q 1/6848 ; CPC C12Q 1/6886 26. Inducible cellular kill-switch — IPC C12N 15/90 ; CPC C12N 15/113 27. Multi-omics organ-on-chip — IPC C12M 3/00 ; CPC G01N 33/50 28. Private synthetic omics data — IPC G06F 21/62 ; CPC G06N 20/00 29. Consent ledger for clinico-omics — IPC G16H 10/60 ; CPC H04L 9/32 30. Edge QC for nanopore sequencing — IPC C12Q 1/68 ; CPC G01N 33/68 31. Single-use bioreactor film sensors — IPC C12M 1/34 ; CPC G01N 33/50 32. RL lab robotics scheduler — IPC G06N 20/00 ; CPC G05B 19/418 33. Online adaptive radiotherapy — IPC A61N 5/10 ; CPC G06T 7/60 34. Inhalable dry-powder LNPs — IPC A61K 9/14 ; CPC A61K 9/127 35. Intention-aware EMG exoskeleton — IPC A61F 5/56 ; CPC A61B 5/11 36. AI bispecific antibody design — IPC C07K 16/00 ; CPC G06N 3/08 37. On-device ECG transformer — IPC G16H 50/20 ; CPC G06N 20/00 38. Breath VOC spectrometry — IPC G01N 33/497 ; CPC A61B 5/00 39. Microbial consortia control — IPC C12M 1/34 ; CPC G05D 1/02 40. Base/prime editing QC — IPC C12Q 1/6848 ; CPC C12Q 1/6886 41. Non-invasive uremia patch — IPC A61B 5/00 ; CPC G01N 33/68 42. Digital pathology QA — IPC G06T 7/00 ; CPC G16H 40/67 43. Omics solvent recycling — IPC B01D 3/00 ; CPC G05B 19/4093 44. GMP digital thread — IPC G05B 19/418 ; CPC G06F 11/36 45. Causal RWE engine — IPC G06F 17/30 ; CPC G16H 50/30 46. Synthetic control arms — IPC G06F 17/30 ; CPC G06N 20/00 47. dMRI motion correction — IPC G06T 7/60 ; CPC A61B 5/055 48. Adaptive proton planning — IPC A61N 5/10 ; CPC G06T 7/60 49. Edge genomic compression — IPC G06F 3/06 ; CPC H03M 7/46 50. Semantic ETL to FHIR-Omics — IPC G16H 10/60 ; CPC G06F 16/28 51. Cuffless blood pressure — IPC A61B 5/024 ; CPC G01N 33/497 52. Contrast dose personalization — IPC A61B 6/00 ; CPC G06T 7/60 53. On-device de-identification — IPC G06F 21/62 ; CPC G16H 10/60 54. Index-hopping contamination — IPC C12Q 1/6811 ; CPC C12Q 1/6886 55. Robotic phlebotomy — IPC A61M 5/36 ; CPC G05B 19/418 56. Adaptive ventilation — IPC A61M 16/00 ; CPC G05D 1/02 57. Microneedle ISF sampling — IPC A61M 37/00 ; CPC C12Q 1/6806 58. Intraoperative hyperspectral AR — IPC A61B 5/00 ; CPC G06T 7/73 59. Granular consent UX — IPC G16H 10/60 ; CPC H04L 9/32 60. Lab heat recovery — IPC F25B 49/02 ; CPC F24F 12/00 61. Smart sterilization indicator — IPC A61L 2/28 ; CPC G01N 31/22 62. Universal transport buffer — IPC C12Q 1/6806 ; CPC C12N 15/10 63. DNA watermarking traceability — IPC C12N 15/10 ; CPC C12Q 1/6886 64. Dataset provenance graph — IPC G06F 11/36 ; CPC G06F 16/2454 65. Synthetic data benchmarks — IPC G06F 17/30 ; CPC G06N 20/00 66. Medical cold-chain drone — IPC B64C 39/02 ; CPC B64U 10/10 67. Health HSM for edge — IPC H04L 9/32 ; CPC G06F 21/57 68. OR scheduling AI — IPC G06N 20/00 ; CPC G06Q 50/26 69. Urine strip spectrometry — IPC G01N 33/52 ; CPC A61B 5/00 70. Ambulatory EEG signal denoising — IPC A61B 5/048 ; CPC G06N 20/00 71. AAV empty/full inline QC — IPC C12Q 1/70 ; CPC G01N 30/86 72. PAT Raman bioprocess — IPC G01N 21/65 ; CPC C12M 1/34 73. Targeted glycoengineering — IPC C12N 15/90 ; CPC C12P 21/02 74. IA-optimized CIP/SIP — IPC A61L 2/28 ; CPC G05B 19/418 75. Gradient cryopreservation — IPC C12N 5/10 ; CPC C12N 5/081 76. Microfluidic endotoxin test — IPC G01N 33/574 ; CPC C12Q 1/04 77. GMP fill-finish vision — IPC B65B 59/00 ; CPC G06T 7/73 78. OCT bioprinting QC — IPC B33Y 80/00 ; CPC G01N 21/45 79. TAVI hemodynamic twin — IPC A61B 6/00 ; CPC G06T 7/60 80. Pressure-sensing stent — IPC A61F 2/82 ; CPC G01L 9/12 81. Rare-disease triage engine — IPC G16H 50/20 ; CPC G06N 20/00 82. LC-MS inter-lab normalization — IPC G01N 33/68 ; CPC C12Q 1/6886 83. Barcoded pool deconvolution — IPC C12Q 1/6848 ; CPC G06F 17/30 84. Vector stability prediction — IPC A61K 48/00 ; CPC G06N 20/00 85. PK/PD TDM-guided dosing — IPC A61P 43/00 ; CPC G16H 20/10 86. Constraint-aware LIMS inventory — IPC G06Q 10/08 ; CPC G16H 10/60 87. Wearable cough analysis — IPC A61B 5/08 ; CPC G10L 25/63 88. Calibrated portable PCR — IPC C12Q 1/16 ; CPC B01L 7/00 89. RBC enzyme hitchhiking — IPC A61K 38/00 ; CPC A61K 9/127 90. Magnetic cell selection feedback — IPC C12N 5/06 ; CPC B01L 3/5027 91. Clinical feature store — IPC G06F 16/2454 ; CPC G16H 10/60 92. Transcutaneous Raman metabolites — IPC G01N 21/65 ; CPC A61B 5/145 93. Thermostable spray-dried vaccine — IPC A61K 39/00 ; CPC A61K 9/14 94. Text-mined adverse event detection — IPC G16H 50/20 ; CPC G06F 17/30 95. Anti-foam bioreactor control — IPC C12M 1/34 ; CPC G05D 1/02 96. Smartphone fundus imaging — IPC A61B 3/10 ; CPC G06T 7/60 97. Photoacoustic sterilant monitor — IPC A61L 2/26 ; CPC G01N 21/17 98. Biologics stability ML — IPC G01N 33/68 ; CPC G06N 20/00 99. Clinical AI ethics cockpit — IPC G06N 20/00 ; CPC G16H 50/30 100. Decentralized self-sampling kit — IPC G01N 33/49 ; CPC H04L 9/32 Keywordsdigital twin, federated learning, clinical decision support, saliva multiplex assay, microfluidics, low-dose imaging, PK/PD simulation, edge AI, sepsis early warning, lipid nanoparticles, exosome QC, adaptive trial design, closed-loop infusion, pre-analytics, spatial transcriptomics, bioreactor monitoring, neuroprosthetics, peptide design, cold chain, portable ultrasound, chronotherapy scheduler, FHIR-omics, MEMS drug delivery, dose reduction pediatrics, calibration service, antibiofilm coating, model auditability, AAV empty/full, PAT Raman bioprocess, glycoengineering, CIP/SIP optimization, controlled cryopreservation, endotoxin microfluidics, aseptic vision, OCT bioprinting QC, TAVI twin, pressure-sensing stent, rare disease triage, proteomics normalization, barcode deconvolution, vector stability, TDM dosing, constraint LIMS, cough analysis, portable PCR, RBC hitchhiking, magnetic cell sort, clinical feature store, transcutaneous Raman, thermostable vaccine, text AE detection, foam control, smartphone fundus, photoacoustic sterilant, biologics shelf-life, AI ethics cockpit, decentralized trial kit.