Nose-To-Brain Targeted Drug Delivery: Impact of Nanoparticles in Alzheimer's Disease Treatment

Alzheimer's disease is a chronic, progressive neurological disorder that is the most common type of dementia linked with memory loss. The Blood-Brain Barrier restricts traditional brain drug delivery. To achieve the desired therapeutic effect, an optimal target was chosen where the drugs are not subjected to systemic circulation. For this purpose, several intrusive and non-intrusive approaches have been examined. Among these, drug delivery from the nasal to the brain via the olfactory and trigeminal nerve system was regarded as the most efficient. Additionally, drug formulation into nanoparticles allows for brain targeting, in addition to controlled release. Nano medicines have attracted immense attention because they can increase drug bioavailability, shorten absorption time, and increase solubility in blood. This review examines the intriguing realm of nanoparticles, which enhance the delivery of drugs from the nose to the brain for the treatment of Alzheimer's disease. The coming years will see the enhancement of human well-being with the inclusion of increasingly advanced methods in drug delivery systems