Theory and formula innovation of the Tongfei Huajie prescription in preventing and treating lung cancer based on the concept of “lung ventilation and Qi regulation”

<x>Abstract</x> <sec> <title>Objectives:</title> To propose a new idea of “lung ventilation and Qi regulation” for preventing and treating lung cancer, and to summarize the corresponding Tongfei Huajie prescription, as a systematic theoretical and practical innovation. </sec> <sec> <title>Methods:</title> Based on the etiology and pathogenesis of lung cancer, the anatomy, physiology and pathology of the lung, and inspired by the ancient “Tuoyue” (bellows) theory, this study combined the clinical observation of ventilation issues in lung cancer patients. The Tongfei Huajie prescription was formulated following the classic principle of monarch (Jun), minister (Chen), assistant (Zuo), and guide (Shi), and was interpreted with modern pharmacological research. </sec> <sec> <title>Results:</title> A novel therapeutic concept of “lung ventilation and Qi regulation” was proposed. The corresponding Tongfei Huajie prescription was developed, which has the effects of ventilating the lung, expelling phlegm dampness, tonifying Qi, tonifying the kidney and spleen for lung health, soothing the liver and descending lung Qi, and clearing the heart and moistening the lung. Clinical application has achieved obvious curative effect. </sec> <sec> <title>Conclusions:</title> This work presents a systematic summary of the innovation in “theory, method, formula and herb” for lung cancer treatment, demonstrating the advantages of Traditional Chinese Medicine in this field. </sec>