The Clinical Efficacy of Autologous Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) in Wound Healing in Small Animals with Special Reference to Dogs

Autologous platelet concentrates — principally platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) — are increasingly used as adjunctive regenerative therapies in veterinary wound management. These haemo-components concentrate platelets and their growth factors (e.g., PDGF, TGF-β, VEGF, EGF), which modulate haemostasis, inflammation, angiogenesis, fibroplasia and re-epithelialization. This review synthesizes peer-reviewed experimental and clinical evidence on the clinical efficacy of autologous PRP and PRF for cutaneous wound healing in small animals, with emphasis on canine studies. Overall, experimental and clinical reports indicate that PRP/PRF accelerate granulation tissue formation, enhance angiogenesis and promote earlier re-epithelialization compared with standard care. However, heterogeneity of product preparation, small sample sizes, variable application protocols and inconsistent outcome metrics limit definitive conclusions and preclude universal clinical recommendations. Priority research needs include standardized production and reporting, randomized controlled trials in naturally occurring canine wounds, and head-to-head comparisons of PRP versus PRF formulations