Formulation and Evaluation of a Polyherbal Gel Containing Solanum Xanthocarpum and Sarcostemma Acidum Plant Extracts

This study reports the formulation and evaluation of a polyherbal topical gel combining extracts of Solanum xanthocarpum and Sarcostemma acidum. The aim was to develop a stable, acceptable gel with enhanced antioxidant and antimicrobial properties for potential wound-care/dermatological application. Extracts were prepared by Soxhlet apparatus, standardized by phytochemical screening and total phenolic content (TPC). Gels were prepared using Carbopol 940 and Sodium CMC as gelling agent with glycerin and propylene glycol as humectants. The final formulations were evaluated for organoleptic properties, pH, viscosity, spreadability, homogeneity, extrudability, in vitro antioxidant , antimicrobial activity (agar-well diffusion), and accelerated stability. Results indicated good physical stability, pH compatible with skin.